Objective To construct a hierarchical prevention scheme for venous thromboembolism(VTE) in orthopedic inpatients,so as to provide scientific and practical guidance for VTE prevention of clinical nurses. Methods Firstly,according to the evidence-based concept,researchers summarized the evidence of VTE prevention scheme,and a preliminary framework was formed. The preliminary prevention scheme consisted of 4 first-level indicators,12 second-level indicators,and 49 third-level indicators. Secondly,2 rounds of expert consultations among 23 doctors/nursing experts were conducted to determine the hierarchical prevention scheme. Results A total of 365 guidelines/expert consensuses were retrieved. Removal of duplicates was conducted for 83 articles,and 112 articles were screened out through reading abstracts. After further reading of the full text,7 guidelines and 3 expert consensuses were finally included. The hierarchical prevention scheme for VTE was constructed through expert consultations that included 4 first-level indicators,12 second-level indicators and 39 third-level indicators. The positive coefficients of experts in 2 rounds of consultations were both 100%,the authority coefficient was 0.863,and the coordination coefficients ranged from 0.111 to 0.192. Conclusion The hierarchical prevention scheme for VTE based on the Caprini scale is scientific. The results of this study can help high risk departments to establish the hierarchical prevention process and path for VTE,providing guidance basis for clinical nurses to carry out VTE prevention and improve patient safety.